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This MDS Sciex API 4000 LC-MS/MS System includes the API 4000 and Shimadzu Nexera system. The Nexera system includes a CBM-20A Communication Bus Module, SIL-20ACXR Nexera CL Autosampler, LC-20ADXR High Presure Pump, LC-20ADXR High Presure Pump, CTO-20AC Column Oven, DGU-20A5R Degassing Unit and Reservoir Tray. A pump and PC (pre-loaded with software), monitor, keyboard, mouse and necessary cables. The API 4000 delivers high-performance quantitation and identification across a wide range of LC flow rates. The system uses the TurboIonSpray probe and the atmospheric pressure chemical ionization (APCI) probe to produce ions from liquid samples. The instrument is configured to perform complex MS/MS analysis, but it can, for less rigorous analytical requirements, perform single MS (LC/MS) scans. The API 4000 LC/MS/MS system allows all modes of MS/MS operation for full characterization of biopharmaceutical compounds and the specificity needed for new drug development. For pharmaceutical and pharmakinetic samples, MS/MS has the sensitivity and specificity required to analyze hundreds of samples per day without extensive sample preparation. For peptides and proteins, molecular weights can be determined with accuracies better than 0.01% at 200 kDa. Features: High sensitivity of the API 4000 System ensures low detection limits Easy-to-use Turbo V Source allows you to quantitate over a wide range of flow rates and to change rapidly between atmospheric-pressure chemical ionization (APCI) and TurboIonSpray Probes. The superior ionization efficiency, enhanced robustness, and ease-of-use of the innovative Turbo V Source, combined with the patented LINAC Collision Cell, delivers high performance and high productivity with greater confidence in your results. Proven Curtain Gas Interface technology, combined with improved gas dynamics, reduces maintenance and increases uptime. Enhanced, high-flow-rate performance, reduced ionization suppression, self-cleaning probe design, and reliable interface are combined to produce accelerated productivity and high throughput. Specifications: Mass Range 5-2800 m/z Dimensions 53" W x 20" D x 21.5" H (130 x 50 x 52.5 cm) Weight 300 lbs. (136 kg) Power 207-242VAC, 50/60Hz, 10A, 2420VA Temperature Range Room temperature to 750°C APCI Temperature 100 to 750°C Flow Range 5 to 3000 µL/min. IonSpray Nebulizer Gas (Gas 1) Zero grade air at 100 psig ±5 psig TurboIonSpray Heater Gas (Gas 2) Zero grade air at 100 psig ±5 psig The Shimadzu Nexera HPLC System Includes: CBM-20A Communication Bus Module SIL-20ACXR Nexera CL Autosampler LC-20ADXR High Presure Pump LC-20ADXR High Presure Pump CTO-20AC Column Oven DGU-20A5R Degassing Unit

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The API 4000 LC-MS/MS System is a scientific instrument used in analytical chemistry for high-performance quantitation and identification of compounds. LC-MS/MS stands for liquid chromatography-tandem mass spectrometry, which combines the separation capabilities of liquid chromatography (LC) with the detection and identification capabilities of mass spectrometry (MS/MS).